Template-Type: ReDIF-Article 1.0
Author-Name:Hafeez Ur Rahman, Jamil Ahmad,NazChughtai,Muhammad Salam, Haseena Noureen
Author-Email:hafeez@uom.edu.pk
Author-Workplace-Name:Department of Computer Science & Information Technology (University of Malakand, KP, Pakistan), Institute of Women’s Health (University College London, UK)
Title:On the Crosstalk of Circadian Rhythm and Th17 cells: An Integrated Biological Regulatory Pathway
Abstract:Th17 cells play a pivotal role in cell-mediated immunity and also have implications for autoimmune disorders. The interplay between the circadian rhythm and the immune system  has  driven  interest  in  developing  novel  therapies.  Th17  cells  have  a  robust relationship  with  the  circadian  rhythm  through  clock-controlled  genes  such  as  NFIL3 (E4BP4),  RORA,  RORB,  NR3C1,and  RORC.  The  purpose  of  this  study  is  to  construct a literature-curatedupdated biological regulatory network (BRN) of the molecular regulators of circadian rhythm and CD4+ Th17 cells. The integrated BRN will provide a holistic view of the  differentiation  process  of  Th17  cells  from  a  circadian  rhythm  perspective,  which  will enhance  our  understanding  of  the  interplay  between  the  two  systems.  We  aim  to  perform formal modelling and analysis of this BRN using our previously developed approaches to gain system-wide insights into various molecular expression dynamics and identify thesignificance of biological clocks in immunity in the future. In addition, biological pathway databases are an integral  part  of  omics  analytical  workflows,  and  their  continuous  updates  with  the  latest knowledge are crucial for gaining biological insights from such studies. Therefore, with this additional  objective,  we  have  also  uploaded  this  pathway  to  WikiPathways  (Database),to facilitate   its   use   in   future   studies,   which   can   be   accessed   via   the   following   URL: https://classic.wikipathways.org/index.php/Pathway:WP5130. To our knowledge, this is the first study to report a literature-curated pathway of comprehensive regulatory interactions and crosstalk between Th17 cell differentiation and circadian genes.
Keywords:CD4+ Th17 cell; Cell-mediated immunity; Circadian rhythm; ROR; NFIL3
Journal: International Journal of Innovations in Science and Technology
Pages:2091-2103
Volume:7
Issue:3
Year: 2025
Month:August
File-URL:https://journal.50sea.com/index.php/IJIST/article/view/1552/2232
File-Format: Application/pdf
File-URL:https://journal.50sea.com/index.php/IJIST/article/view/1552
File-Format: text/html
Handle: RePEc:abq:IJIST:v:7:y:2025:i:3:p:2091-2103